Amiodarone, a potent antiarrhythmic, is known to cause pulmonary toxicity
Amiodarone was discontinued and the patient was treated with oral prednisone 50 mg daily
In this case series, we describe the clinical, radiographic, and histologic manifestations of three patients who developed interstitial lung disease (ILD) following amiodarone treatment for variable lengths of time with different dosages
breathing in dust or other particles in the air are responsible for some types of interstitial lung diseases
These disorders are characterized by a reduced distensibility of the lungs, compromising lung expansion, and, in turn, reduced lung volumes, particularly with reduced total lung capacity (TLC)
Radiation Cases of interstitial lung disease (ILD) have also been recently described, Amiodarone, known to be associated with ILD, was used as a positive control, and warfarin was also analyzed as a reference
ILA is defined as incidental CT findings of nondependent abnormalities affecting more than 5% of any lung zone (ie, upper, middle, and lower lung zones are demarcated by the levels of the inferior aortic arch and right inferior pulmonary vein) at complete or partial chest CT (eg, abdominal or cardiac CT
However, pulmonary toxicity can also appear in various forms The pattern for drug-induced lung injury may vary in many forms, but amiodarone can cause polymorphous injuries such as diffuse alveolar damage (DAD), chronical interstitial pneumonia (CIP), organizing pneumonia, pulmonary hemorrhage, lung nodules or pleural disease [20,21]
Clinical features are varied
3 Pulmonary nodular lymphoid hyperplasia
Lung parenchymal opacities in amiodarone have increased attenuation and this finding is suggestive, but it is not pathognomic of amiodarone-induced pulmonary toxicity Drug-induced interstitial lung disease has been reported as a severe adverse effect of some drugs, such as bleomycin, amiodarone, and methotrexate
It is used to treat a variety of malignancies, connective tissue diseases, and also psoriasis
People recover well if they detect lung problems early and stop the medication
Symptoms of drug-associated interstitial lung disease (ILD) are nonspecific and can be difficult to distinguish from a number of illnesses that commonly occur in patients with non-small-cell lung In this review we present the key findings in the most common interstitial lung diseases