This activity describes the indications, action, and contraindications for phenytoin as a valuable agent in the treatment of epilepsy
PMID: 18609434
To some degree, the cellular effects of antiseizure medications are linked with the types of seizures against which they Neutropenia is defined as an absolute neutrophil count (ANC) <1500/microL
DILANTIN 100 mg: Active ingredient: 100 mg phenytoin sodium, USP Inactive ingredients: lactose monohydrate, confectioner's sugar, talc, and magnesium stearate
Platelets are also called thrombocytes, because a PATHOGENESIS
Immune thrombocytopenia, often known as immune thrombocytopenic purpura (ITP), has emerged as an important complication of COVID-19
Thrombocytopenia can be mild, moderate, or severe
Thrombocytopenia can generally be classified as mild, moderate, or severe (Table Table1 1)
A 15-year-old boy developed thrombocytopenia and purpura two weeks after starting phenytoin therapy
Reported reactions in phenytoin-treated patients have included toxic epidermal necrolysis (TEN), These have included thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without bone marrow suppression
The etiology These drugs are associated with a range of hematologic disorders ranging from mild thrombocytopenia or neutropenia to severe anemia, red cell aplasia, or bone marrow failure
These have included thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without bone marrow suppression
(2) This argues against processes which promote thrombosis (e
Because serum folate levels fluctuate with dietary intake Which lab finding would alert the nurse to hold the administration of phenytoin and notify the health care provider? albumin level of 2
There are two types of drug-induced thrombocytopenia: immune and nonimmune
Patients and methods: An 8-year-old girl had fever, rash, thrombocytopenia, and leukopenia 18 days after initiation of phenytoin therapy
phenytoin, gentamicin, vancomycin, ranitidine, digoxin; unfractionated heparin (UFH) prophylaxis was started on postoperative day 3
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In a case report by Salzman et al3, a rapid rise in platelet count was associated with the administration of intravenous immunoglobulin in a 8 year old child with phenytoin induced thrombocytopenia and leukopenia
There was an increase in immature neutrophils but no abnormalities were present in other cell lines
Common Dilantin side effects may include: drowsiness, confusion; slurred speech; Phenytoin-induced thrombocytopenia was reported for the first time in 1986 by Brown et al
This topic review discusses drug-induced immune thrombocytopenia (DITP), in which the mechanism involves antibody-mediated platelet destruction caused by exposure to a drug that leads to isolated thrombocytopenia (without anemia or leukopenia)
Discussion: Phenytoin has been reported to induce various hematologic reactions, including thrombocytopenia
People with platelet disorders such as von Willebrand disease, abnormal platelet function from uremia, and a low platelet count (thrombocytopenia) are advised
Introduction Hematological disorders arise through a variety of mechanisms and etiologies
While
thrombocytopenia due to clearance and/or destruction of platelets sensitized by a drug-dependent antibody
g
The prevalence and degree of thrombocytopenia increase with the severity of liver disease and correlates to hepatocellular damage and hepatic fibrosis
To some degree, the cellular effects of antiseizure medications are linked with the types of seizures against which they Dilantin (phenytoin) is a seizure medication (anticonvulsant) used to prevent or treat seizures
It is often discovered incidentally when obtaining a complete blood count during an office visit
In vitro studies demonstrated a phenytoin-dependent antigranulocyte antibody directly implicating phenytoin in the leukopenia
When you are injured, platelets stick together to form a plug to seal your wound
Patients with cirrhosis may be prone to bleeding due to elevated portal pressure with formation of varices, decreased hepatic synthesis of procoagulant proteins, thrombocytopenia, and platelet dysfunction
in a case report of a 35-year-old male with a dropped platelet counts of 15×10 9 /L after 2 weeks of phenytoin initiation
I Purpose: To describe the use of intravenous immune globulin (IVIG) in an 8-year-old girl with phenytoin-induced thrombocytopenia and leukopenia
It is a water-soluble phenytoin prodrug that can be employed in situations where
The patient has recently developed thrombocytopenia
There was an increase in immature neutrophils but no abnormalities were present in other cell lines
Clozapine, a dibenzodiazepine, is an atypical antipsychotic medication used in the treatment of schizophrenia resistant to conventional neuroleptic agents
The patient had also been taking cimetidine for 2 months prior to admission
Thrombocytopenia caused by drugs is a particularly vexing clinical problem
This case of phenytoin-induced thrombocytopenia emphasizes the importance of recognizing thrombocytopenia secondary to drug use and also highlights a lesser known but important interaction between phenytoin and dexamethasone to enhance this effect
A patient was discharged 3 days ago on phenytoin therapy for seizure disorder