See more Jul 1, 2007 This article outlines the management approach (intensified treatment) and
However, there are limited data on the effectiveness of glyburide when compared with
Even patients with mildly elevated glucose levels who do not meet
If glucose levels remain above target values, pharmacologic therapy with
Uses Warnings Before taking Side effects Dosage
Insulin is the gold standard for treatment of hyperglycemia during pregnancy, when
Until further data is available, it is prudent not to use this drug in pregnancy
9 mmol per liter) in the glyburide group and 105±18 mg per deciliter (5
Insulin is the recommended method of controlling blood sugar during pregnancy
All providers who care for the women with GDM should be able to determine ideal candidates for this medication
1 mcg/L on day 6, although the times with respect to the dosage were not reported
Glyburide also crosses the placenta, although less so than metformin, and it is possible that if fetal concentrations are sufficient, glyburide could directly stimulate the fetal β-cells and cause fetal hyperinsulinemia (13,26)
7 to 1
Glyburide is an adjunct therapy along with diet and exercise for managing diabetes
Increased risk of hypoglycemia; hypoglycemia may be difficult to recognize
In rat reproductive studies, mild fetotoxic effects were observed at dose levels from 5 to 50 mg/kg
Glyburide hasn't been well-studied in human pregnancy, so it's not known whether this medication will cause harm to unborn babies
Taking metformin during pregnancy may be linked to low birth weight in newborns
Metformin and glyburide may be used, but both cross the placenta to the fetus, with metformin likely crossing to a greater extent than glyburide
55 This is due to the pregnancy-related up-regulation