argentea has shown highest α-amylase and α-glucosidase inhibitory potential with IC 50 values of 0
125 and 0
05 ± 4
Alpha-amylase inhibition potential of WFLE is demonstrated in Figure 3
azedarach, however, showed less inhibitory
1 Altmetric Metrics Abstract In the present work, a new series of 14 novel phthalimide-benzenesulfonamide derivatives 4a – n were synthesized, and their
The strategy of reducing carbohydrate digestibility by controlling the activity of two hydrolyzing enzymes (α‐amylase and α‐glucosidase) to control postprandial
Alpha amylase inhibitory activity was calculated as percentage inhibition using the formula, % Acarbose with an IC50 of 133
47 µM)
22 ± 0
africana (250, 500, and 750 mg/kg) leaves extracts were evaluated for their effects on alpha amylase and alpha
The IC50 values for baicalein, (+)-catechin, quercetin, and luteolin Acarbose inhibits alpha-amylase through a mixed, noncompetitive inhibitory effect and is a competitive inhibitor of alpha-glucosidases, found in the intestinal brush border with higher selectivity Acacia catechu, Dioscorea bulbifera, and Swertia chirata exhibited inhibitory activity against α-amylase and with IC50 values; 49
1 µg/mL respectively, while 4 and 1 demonstrated strong alpha-amylase inhibitory activity amongst the isolated compounds
125, 1
4) Add Alpha-amylase inhibitors are mainly present in plants and the most studied molecules are glycoproteins isolated from kidney beans (Phase 2 ® product) (reviewed in Barrett and Udani 2011)
40 μ g/mL, respectively
There is no statistically significant
5 μg/μL); while α-glucosidase results showed not statistically differences between groups QSAR model predictions showed that the designed molecules exhibited a higher potential biological level activity IC50 than acarbose used in positive control (IC50= 1
17 ± 0
Though results showed pu-erh tea has significant inhibitory effects on alpha-amylase and alpha-glucosidase, high heterogeneity was detected among studies included
28 and 599
They were conducted in an identical fashion replacing tests with 1 mL of the solvent
Acarbose was used as positive control (IC50: 23
3