The manufacturer's recommendations for cephalexin dosages for patients with renal impairment are listed below
Dosage
Side effects
SUMMARY
Renal function Dose regimen recommendation Creatinine clearance > 60 mL/min No
(2
Your doctor may adjust your dose if you have kidney disease
In animal reproduction studies, pregnant mice and rats administered oral cephalexin doses of 250 or 500 mg/kg/day (approximately 0
4
125 mg once daily, dose to be taken at night, alternatively 500 mg for 1 dose, following exposure to a trigger
Parenteral options include cefazolin, nafcillin, and flucloxacillin
Monitoring
The oral cephalosporins are generally well tolerated; adverse events can include diarrhea, nausea, abdominal pain High doses and overdoses have led to blood abnormalities, including low white blood cell counts (neutropenia)
Safety Tips to Consider Before Giving your Pooch Cephalexin
CrCl 35-54 mL/min: Give recommended dose at intervals ≥8hr; CrCl 11-34 mL/min: Give half of recommended dose q12hr especially of: kidney disease, liver disease, stomach/intestinal diseases (such as colitis)
Given the paucity of large pharmacokinetic studies, dosing
In contrast, some medications may require dose reduction or cessation as a result of advancing stages of
5% with the addition of a pharmacist attending medical rounds and offering dose
S
Therefore, appropriate antibiotic dosing is imperative to achieve positive patient outcomes while minimizing antibiotic dose-related toxicity