You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications
Severity: Severe
gastrointestinal obstruction
Unless otherwise stated, interacting medications should be managed (held/dose reduced/extra monitoring) for 8 days from the first dose of Paxlovid
Effect of ritonavir on drug‐metabolizing enzymes and drug transporters
There are 653 drugs known to interact with ritonavir, along with 5 disease interactions, and 2 alcohol/food interactions
How it works Codeine is an opioid analgesic (pain reliever) that is related to morphine
Drug interaction studies opioid therapies (methadone, buprenorphine) and new ARV (eg, maraviroc, etravirine) and medications currently in development
PAXLOVID includes ritonavir, a strong CYP3A inhibitor, which may lead to greater exposure of certain concomitant medications, resulting in potentially severe, life-threatening, or fatal events
Drug interactions secondary to inhibition of the CYP 450 enzyme system are likely the most well known of all drug interactions, and they occur more frequently than enzyme induction
Dr
The relevance of a particular drug interaction to a specific individual is difficult to determine
Ritonavir (Indian Council of Medical Tylenol With Codeine may interact with several medications that are metabolized through the same liver enzymes CYP3A4 or CYP2D6
Of the total drug interactions, 69 are major, 6 are moderate, and 91 are minor
It is important to tell your doctor about all other Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, or sweating may occur
Paxlovid disease interactions
Acetaminophen/codeine is a combination of two different pain-relieving medicines (acetaminophen and codeine) with two different mechanisms of action
Both Quetiapine and Codeine can cause sedation, which might affect the ability to perform skilled tasks Ritonavir is predicted to increase the exposure to Quetiapine
Check with your healthcare provider if you have questions about ritonavir interactions
With certain long-acting formulations of narcotic pain medication, consumption of interaction potential of ritonavir-boosted nirmatrelvir may change if it is used for extended durations
See the list of drugs that interact with Hydroxycarbamide
Hypotension