Allopurinol Hypersensitivity Syndrome: A Review DOI: PubMed Authors: Félix Arellano Jose Antonio Sacristan Lilly Spain Abstract To review the pathophysiology
Skin Rash and Hypersensitivity: Discontinue ALOPRIM at the first hypersensitivity reaction
[3] : 119 Weeks to months after allopurinol is begun, the patient develops
Stevens-Johnson syndrome (SJS) is one of the life threatening severe cutaneous adverse reactions caused by allopurinol
Le syndrome d’hypersensibilité à l’allopurinol inclut le syndrome de Stevens–Johnson, le syndrome de Lyell et la réaction médicamenteuse avec éosinophilie et symptômes systémiques
31 In addition, PDF | Allopurinol is a commonly used medication that lowers uric acid production which is essential for gout treatment and prevention
The records of 38 patients with the allopurinol hypersensitivity syndrome evaluated at the Veterans General Hospital-Taipei were reviewed
2) •Hepatotoxicity: If signs and symptoms of hepatotoxicity develop, liver Although many patients tolerate allopurinol therapy without severe complications; Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life-threatening delayed hypersensitivity reactions that have been reported especially among Asian and African American patients
The frequency of this allele is higher in individuals of African, Asian (e
The pathophysiology of allopurinol-induced hypersensitivity, clinical presentation and treatment are reviewed and the term DRESS syndrome was recently introduced to describe a disorder associated with various drugs or viral infections and characterized by similar features
Eight of the 8 patients with the allopurinol hypersensitivity syndrome evaluated at the Downstate Medical Center hospitals and an additional 72 patients described in the literature were reviewed, and severe, often fatal iatrogenic disease occurred unnecessarily in the others
The other Allopurinol hypersensitivity syndrome is a life-threatening cutaneous adverse reaction that should be initiated under clear indications with appropriate dosages, and potential associations with this syndrome include the Chinese race, the elderly, and patients with underlying renal impairment
The term allopurinol hypersensitivity syndrome (AHS) has been coined to encompass the plethora of features caused by hypersensitivity to allopurinol
Historical risk factors for AHS include renal insufficiency and diuretic