Under this protocol, patients with BMI >40 Kg/m2 were dosed using adjusted body weight (AdjBW) and patients with BMI <40 Kg/m2 were dosed using ABW
Drug Name
Conclusions: Intravenous dosing of acyclovir for herpes encephalitis is variable, especially in obese patients, and does not reflect recommendations
The original package insert recommends dosing on ideal body weight in obesity
50-59 kg = 400 mg PO qAM PLUS 600 mg PO qPM
3 x height in inches > 60 inches) ∙ Adjusted Body Weight ABW (kg) = IBW + 0
In non-obese patients, Total
reference
1128/AAC
As patient weight increased, respondents were more apt to dose based on an adjusted body weight, with dosing in the obese and morbidly obese showing a
acyclovir sodium 5mg/kg dosed by adjusted body
The median BMI [interquartile range (IQR)] for all patients was 34
Acyclovir is a widely used antiviral agent used to treat viral meningitis
Obese Patients: Obese patients should be dosed at recommended adult dose using Ideal Body Weight
5 kg
The preferred formula to guide dosing is not certain at this time, but eCrCl based on actual body weight and measured
) acyclovir dose to be based on total body weight (TBW); however, in obese patients it recommends dosing by ideal body weight (IBW)
Dosing: Adult Antimicrobial Dosing, Non-dialysis
5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period, and repeated every eight hours for five to ten days
4(Actual Weight – Ideal Weight) + Ideal Weight • Adjust vancomycin, meropenem, acyclovir, TMP-SMX and aztreonam in patients with renal dysfunction • CT prior to lumbar puncture if: o Immunocompromi sed o History of CNS disease (mass The study included 51 adult patients with a body mass index (BMI) greater than or equal to 30 kg/m^2 who received at least 48 hours of high-dose IV acyclovir therapy
Acyclovir-associated nephrotoxicity was not associated with dosing weight utilized (P >
053)
Children up to 12 years of age—Dose is based on body weight and must be determined by the doctor
The currently recommended dosing strategy at our institution for obese patients is to receive intravenous acyclovir dosed per an adjusted body weight [IBW + 0