Indications, Mechanism of Action, Administration, Adverse Effects, Contraindications, Monitoring, Enhancing Healthcare
While not specifically related to the mechanism of action in gout, febuxostat, unlike allopurinol, is a substrate of uridine diphosphate glucuronosyltransferase (UGT) 1A1
Other mechanisms of action for allopurinol include decreased macrophage interleukin 1-beta (IL1β) secretion upon the activation of NLRP3 inflammasome [48, 49]
Allopurinol inhibits xanthine oxidoreductase (XOR), which catalyzes the final two steps of purine catabolism, the oxidative hydroxylation of hypoxanthine to xanthine and
Medication Mechanism of action Dosage Special considerations; Clinical pharmacology and mechanism of action
It can take 2-6 weeks before allopurinol produces a 12
Mechanism of Action: Allopurinol inhibits xanthine oxidase, the enzyme that catalyses the conversion of hypoxanthine to xanthine then to uric acid
In August 2017, a combination oral therapy consisting of lesinurad and Allopurinol was FDA-approved under the brand name Duzallo indicated for the treatment of gout-related hyperuricemia in patients with uncontrolled gout
competitive inhibition of xanthine oxidase, which decreases production of urate
It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation
It is a xanthine oxidase inhibitor and is similar to febuxostat ( Uloric )
Allopurinol is converted to oxypurinol at the molybdenum center of XOR, and oxygen is received from the water molecule (top)
Allopurinol
Which of the following best describes the mechanism of action of the drug indicated to treat this patient’s condition? Allopurinol is a purine analog that works by competitive inhibition of xanthine oxidase
Who can and cannot take it
It is an inhibitor of xanthine
Microtubules, key components of the cytoskeleton, are made up of αβ-tubulin heterodimers
5