One of the key targets for metastatic cancer cells is the skeleton
A monoclonal antibody
Bone metastasis occurs when
Metastatic cancer-induced bone pain (CIBP) is a type of chronic pain with unique and complex pathophysiology characterized by nociceptive and
Chemotherapy
Cyclic progestin prevents bone loss in healthy premenopausal women with amenorrhea or SOD
An adjuvant pain medication should be considered at all stages of the World Health Organization’s pain ladder for mild to severe pain
Treatments that specifically address bone metastases are: Radiation therapy: A local therapy that can significantly reduce both pain and the likelihood of a fracture
This procedure can reduce pain
It is associated with significant morbidity, including bone pain, hypercalcemia, pathologic fractures and spinal cord compression—an oncologic emergency causing pain and potentially
Bone is one of the most frequent sites of spread for many common cancers such as breast, prostate, lung, and kidney and is usually affected in multiple myeloma
Bisphosphonates are commonly used in patients with breast or prostate cancer with bone metastases or multiple myeloma, and have been shown to be effective in reducing bone pain and the occurrence of SREs, either when used alone or concomitantly with radiation therapy [8, 16, 17, 40-43]
Bone metastases are common in patients with solid tumors (especially for prostate, breast, lung, and kidney cancers), and the spine is the most significant site of advanced disease (), whereas lesions in flat and
It is usually related to weight-bearing or movement and can lead to pathologic fractures
Pain flare is described as a temporary increase in bone pain at the treated metastatic site, during or shortly after RT completion
9 This could be secondary to cancer disease events such as hemorrhage into a tumor, bone pain secondary to a pathological fracture, visceral pain
Metastatic bone cancer treatments may include: Surgery: The care team may perform surgery to remove affected cancer cells, depending on the stage, location and size of the bone cancer
1) Cancer-induced bone pain
Fortunately, non-steroidal anti-inflammatory medications
Painful osseous metastases are typically associated with multiple episodes of breakthrough pain which may occur with activities of daily living, weight bearing, lifting, coughing, and sneezing