Mirtazapine (MTZ) is an atypical antidepressant approved by the FDA, which mechanism of action involves the antagonism of alpha-2, H1, 5-HT2A, 5-HT2C, and 5
Drowsiness Drowsiness is a common mirtazapine side effect — with more than 50% of people in clinical trials reporting it
Since the movement disturbances did not appear to occur until after addition of the SSRI, it is possible that pharmacokinetic interactions may have occurred -- leading
Akathisia Akathisia is a common, but often under-recognised, drug-induced movement disorder that can occur as an acute, subacute or tardive reaction
Serious side effects of mirtazapine are rare and happen in less than 1 in 10,000 people
Trazodone is a widely used antidepressant that can cause tardive dystonia, a movement disorder affecting the face and jaw
KH’s improved mood at this lower dose might
Drugs like this one have raised the chance of suicidal thoughts or actions in children and young adults
They're usually mild and go away after a couple of weeks
Comments: May increase the dose every 1 to 2 weeks to a maximum 45 mg/day according to patient response
If any of these effects last or get worse Severe skin reaction
3, 21 – 23 Unlike the SSRIs, mirtazapine is associated with a very low incidence of sexual REMERON is supplied for oral administration as scored film-coated tablets containing 15 or 30 mg of mirtazapine, and unscored film-coated tablets containing 45 mg of mirtazapine
Common questions
As an antidepressant, mirtazapine has proven to be equally as effective as the tricyclic antidepressants and trazodone in patients with moderate-to-severe depression in both inpatient and ambulatory settings
risk of profound CNS and resp
Some side effects may occur that usually do not need medical attention
Do not break, crush or chew them
These effects must be balanced with mirtazapine's ability to cause sedation-related side effects Agranulocytosis: If sore throat, fever, stomatitis or signs of infection occur, along with a low white blood cell count, treatment with mirtazapine tablets should be discontinued and the patient should be closely monitored
Well absorbed from the GI tract following oral administration, with peak plasma concentration usually attained within 2 hours
There are 647 drugs known to interact with mirtazapine, along with 13 disease interactions, and 2 alcohol/food interactions
Mirtazapine is a tetracyclic piperazino-azepine antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994
The increased release of serotonin (5-hydroxytryptamine; 5-HT) stimulates serotonin 5-HT1 receptors because mirtazapine
Itching can be uncontrollable and persistent, lasting for some time before subsiding
It also has a slight sedative effect, which is how it can also improve sleep [3] [4]