Once a therapeutic blood level is achieved, stable renal transplant recipients are generally maintained on a cyclosporine dose of 3 to 6 mg/kg/d administered in 2 equally divided
Open access
Tacrolimus is a widely used calcineurin inhibitor immunosuppressant drug for recipients of renal transplants
Renal transplantation
References
despite the Tacrolimus
The only exceptions to this
12 The present study uses 1,930 recipients from this study who received TAC
Tacrolimus nephrotoxicity occurs in-17 to 44% of renal transplant recipients and in 18 to 42% of liver transplant recipients in 9% of subjects
One of the key challenges in using TAC is therapeutic drug monitoring (TDM) of
To prevent kidney transplant rejection: Adults—Dose is based on body weight and must be determined by your doctor
Introduction
In combination with mycophenolate mofetil, prednisolone and daclizumab, Tac regimen showed a superior graft function, better prevention of acute rejection and superior graft survival after 12 months Introduction
Tacrolimus (or FK506), a calcineurin inhibitor (CNI) introduced in field of transplantation in the 1990s, is the cornerstone of most immunosuppressive regimens in solid organ transplantation
Both drugs have been isolated from fungi and possess similar suppressive effects on cell-mediated and humoral immune responses
Refer to AKI section
Tacrolimus is an immunosuppressant drug with a narrow therapeutic index
3 Dosing for Adult Kidney, Liver, or Heart Transplant Patients - Capsules and Injection
Tacrolimus, a calcineurin inhibitor, is a widely acceptable used immunosuppressive drug in kidney transplant recipients (KTRs)
A different strategy to minimize immunosuppression is therefore to maintain tacrolimus as the cornerstone of modern post kidney transplant immunosuppression, and to wean both steroids as well as mycophenolate mofetil
Tacrolimus has a narrow therapeutic index and dosing can be challenging due to its high intra- and inter-patient variability (Venkataramanan et al
While the nephrotoxicity of long-term tacrolimus exposure is well characterized, 4,5 tacrolimus may be also be acutely nephrotoxic at high levels due to afferent arteriolar vasoconstriction in the glomerulus
Therapeutic ranges are based on specimen collected at trough (ie, immediately before a scheduled dose)