Weight: 29
Apr 25, 2016 · As with all drugs, it is important to treat the patient and not the number
Once the seizures are controlled, some people may be able to switch to the 300 mg capsule once-daily
Maintenance dose: Individualized; generally, a dose that provides Sep 21, 2020 · In a woman taking phenytoin 500 mg daily in 2 divided doses 12 hours apart, breastmilk phenytoin levels were 0
Normal maintenance dosage is then instituted 24 hours after the loading dose, with frequent serum level determinations
The Complete (but Practical) Guide to Phenytoin Dosing — tl;dr pharmacy Get better at pharmacy
Therapeutic drug monitoring of phenytoin is necessary to ensure dosage delivery is at therapeutic levels
Risk of hypotension and arrhythmias with infusion rates that exceed 50 mg/min in adults and 1-3 mg/kg/min (or 50 mg/min, whichever is slower) for pediatric patients
Once-a-day dosage: In adults, if seizure control is established with divided doses of three 100-mg DILANTIN (extended phenytoin sodium capsules, USP) daily, once-a-day
Phenytoin doses are usually selected to attain therapeutic plasma total phenytoin concentrations of 10 to 20 mcg/mL (unbound phenytoin concentrations of 1 to 2
The recommended starting dosage for adult patients who have received no previous treatment is 5 mL (125 mg/5 mL), or one teaspoonful, by mouth three times
The usual therapeutic range for total (unbound + bound) phenytoin serum concentrations when the drug is used in the treatment of seizures is 10–20 μ/mL
DOSAGE FORMS AND STRENGTHS----- Injection: 50 mg phenytoin sodium equivalents (PE)/mL available as: •10 mL single-dose injection vials, each containing 500 mg PE (3)
To calculate the dose of the syrup: Liquid dose = Dose/Concentration
Rockville, MD 20852 • Kaiser Foundation Health Plan of the Northwest, 500 NE Multnomah St
an initial dose of 500 milligrams (mg) followed by 250 mg once daily until day 5: mild-to-moderate bacterial COPD exacerbations: 500 mg per day for 3 days OR phenytoin, a seizure medication; The dose of phenytoin is typically adjusted to the needs of the individual patient to achieve adequate control of seizures, preferably with monitoring of plasma concentration; in many patients, control requires total plasma phenytoin concentrations of 10–20 µg/mL (40–80 µmol/L), but some are satisfactorily controlled at concentrations Subsequently, the usual average half-life of 22 hours can become significantly prolonged with marked overdose
Excipients with known effect
Usual Adult Dose for: Upper Respiratory Tract Infection; Bronchitis; Otitis Media; ER tablets given 500 mg orally 2 times a day are only clinically equivalent to IR capsule formulations given 250 mg orally
Once-a-day dosage: In adults, if seizure control is established with divided doses of three 100-mg DILANTIN (extended phenytoin sodium capsules, USP) daily, once-a-day dosage with 300 mg of DILANTIN (extended phenytoin sodium capsules, USP) may Epanutin dosage
A: Shake a volume of Oral Suspension, equivalent to about 100 mg of phenytoin, with 50 mL of a mixture of ether and chloroform (1 in 2) in a separator, evaporate the extract to dryness, and dry in vacuum at 105 for 4 hours: the phenytoin so obtained melts between 292 and 299 Phenytoin Sodium Injection, USP—50 mg/mL
Maintenance: 4-8 mg/kg/day orally; not to exceed 300 mg/day; higher doses may be considered in infant and young children (range: 8-10 mg/kg/day in divided doses) Extended-release
Alternative tapered regimen: 10 mg/kg orally 4 times a day for 14 days, then 10 mg/kg orally 2 times a day for 7 to 14 days, then 10 mg/kg orally every 2 to 3 days for 2 to 8 weeks
The recommended initial dose is 15 mg/kg/day, increasing at one week intervals by 5 to 10 mg/kg/day until seizures are controlled or side effects preclude further increases
Phenytoin tablets, capsules, and oral suspension contain different formulas of the drug
Because of this, unbound or “free” phenytoin Study with Quizlet and memorize flashcards containing terms like A nurse is preparing to administer valproic acid (Depakote) 45 mg/kg/day PO divided in equal doses every 8 hr to a child who weighs 78 lb
These errors have resulted in two- or ten-fold overdoses of CEREBYX since each of the vials actually contains a total of 100 mg PE (2 mL vial) or 500 mg PE (10 mL vial)