Isoniazid is an antibiotic used in the treatment of mycobacterium tuberculosis infections
Call your doctor right away if you have signs of
DRUG-SUSCEPTIBLE TUBERCULOSIS: Intensive Phase: 10 to 15 mg/kg orally once a day PLUS rifampin, pyrazinamide, and ethambutol
The drug should be restarted in very small and gradually increasing doses and
Isoniazid tablets, USP are recommended for all forms of tuberculosis in which organisms are susceptible
Some of the most common side effects include fever and a reaction to the
At first sign of hypersensitivity, discontinue all drugs and evaluate patient
Usual Pediatric Dose for Tuberculosis - Active
Severe and sometimes fatal hepatitis has been reported with isoniazid therapy and may occur even after many months of treatment
Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes
Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs
Children younger than 15 years of age—Use and dose must be determined by your doctor
Avoid or Use Alternate Drug
Isoniazid is also used in the treatment of latent TB infection and multidrug-resistant TB treatment (at high dose - Hh)
Medscape UK - Indication-specific dosage for Rifampicin with isoniazid tablets, precautions and warnings, side effects, pregnancy and lactation, contraindications and full drug monograph Oral formulations of rifampicin and isoniazid
Effects of Drug Abuse
Adult: In combination with other antitubercular agents: Usual dose: 5 mg/kg (up to 300 mg) daily as a single dose, or 15 mg/kg (up to 900 mg daily) given 2 or 3 times weekly via slow IM or IV inj
Newly infected patients
1–49
gov
Administer concomitantly pyridoxine (vitamin B 6 ): child: 1 to 2 mg/kg (usual range: 10 to 50 mg) once daily; adult: 100 mg once daily
New formulations with larger dosage per tablet and fixed-dose INH-RPT combinations are in development