Objectives: Apply current guidelines for managing Chronic Pulmonary Aspergillosis (CPA), which encompasses simple
Chronic pulmonary aspergillosis
OBJECTIVE:To review the role of itraconazole as oral therapy for the major infections
There have been no controlled trials of itraconazole as treatment for aspergilloma, but
Although itraconazole offers promise for oral therapy against infections caused by Aspergillus spp
0 g, should remain the treatment of choice in both aspergilloma and invasive aspergillosis
In a 12 month open study of itraconazole in pulmonary aspergilloma nine patients received oral itraconazole 200 mg daily for six months followed by further itraconazole or observation for a further six months
1988 Sep;31(9):476-85
This again disappeared at 100 mg tid of Itraconazole
Long-term treatment with itraconazole may be beneficial in stabilising patients' general condition, Surgical resection of aspergilloma is a definitive treatment option for patients with adequate pulmonary function (SoR A and QoE II) [124, 125]
The roles of systemic glucocorticoids and antifungal agents vary with the disease activity
Patients with aspergilloma can be safely managed with supportive therapy in absence of massive haemoptysis
Predominantly it affects patients with bronchial asthma and those having cystic fibrosis
Antifungal Guideline for Invasive Fungal Infections in Adults, June 2019
The role of newer antifungal azoles such as voriconazole in the treatment of aspergilloma has yet to be determined
The optimal dose, duration, and efficacy of itraconazole in Indian patients of pulmonary aspergilloma (PA) are not clearly defined
Manifests as a subacute pneumonia unresponsive to antibiotic therapy, which progresses and cavitates over weeks or months
Intravenous itraconazole circumvents problems with intestinal absorption
The clinical presentation of Aspergillus lung disease is determined by the interaction between fungus and host
If you are diagnosed with allergic bronchopulmonary aspergillosis, an antifungal medication, such as itraconazole, is the most common course of action