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Average value Tmax time of 1 hour while taking letrozole fasting 2 h and - when taken with food; Cmax is the mean value (129 ± 20,3) nmol / l in the fasted and (98,7 ± 18,6) nmol / l - when taken with food, but the degree of suction letrozole (as assessed by AUC value) does not change
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At least 75% of the radioactivity was detected in the urine for a period up to 216 hours (84,7 ± 7,8% of the dose of letrozole) had to glucuronide conjugates carbinol metabolite, about 9% - for the other two unidentified metabolites, and 6% - on unchanged letrozole
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