FDA-Approved Indications VPA holds FDA-approved indications for a diverse range of neurological and psychiatric conditions, as listed below
Valproic acid (VPA) and its derivatives
Neuromonitoring Waking & weaning Supportive medical management Approach to medication selection Selection of antiseizure medication (s) Selection of
Indications and dose For valproic acid For Convulex® Unlicensed use For valproic acid Not licensed for migraine prophylaxis
Dis
Monitor Depakote levels, liver function tests, and CBC with diff every 3-6 months
Therapeutic blood monitoring can be conducted once steady state is achieved Valproic acid (VPA) ia as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders
VALPA
Therapeutic drug monitoring
2 The enteric coating delays tablet dissolution and absorption until after the compound has progressed past the stomach
4,5,6 Following oral administration, both drugs are well-absorbed Therapeutic monitoring: Observing valproic acid levels helps healthcare professionals ensure the drug is within the therapeutic range, which means it’s at a concentration that effectively treats Valproic (val-PRO-ik) acid is the generic name (non-brand name) of a widely used type of seizure medicine
The largest barrier to regu-larly monitoring free levels is the absence of widely available free valproic acid as-says
Hepatotoxicity occurs in very young children, most often those on multiple anticonvulsants
If you notice any of these side effects, tell your doctor right away
The variability in free fraction limits the clinical usefulness of monitoring total serum valproic acid concentrations
For migraine: Adults—At first, 250 milligrams (mg) 2 times a day
Check with your doctor right away if you have the following symptoms: a fever, dark urine, headache, rash, stomach pain, swollen lymph glands in the neck, armpit, or groin, unusual tiredness, or yellow eyes or skin
If it is necessary to discontinue lamotrigine, it should be done in a step-wise fashion over two weeks, if possible