Clozapine is an atypical antipsychotic agent displaying unique effectiveness in the treatment of refractory schizophrenia
Uses Warnings Before taking Dosage Side effects Interactions What is clozapine? Clozapine is an antipsychotic medicine
Most clozapine ADEs emerge within 3 months, and almost all appear within 6 months, after initiation
Heart disease: signs of a problem include chest pain, palpitations, or a rapid pulse
Different solutions of clozapine (standard and tablet) at 10 mg/L and catalyst (100 mg/L) were prepared and irradiated (Suntest), with different additions of isopropyl
There are a number of changes in the pharmacokinetics and pharmacodynamics of clozapine in elderly patients, which warrant particular caution
Because it is associated with severe and potentially fatal side effects (agranulocytosis), its use is restricted to
Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical"
Use with caution in patients with a history of seizures or other predisposing factors (e
12 , 27 , 28 The patient’s psychiatrist should be consulted before any changes
The Clozapine Products Manufacturers Group proposed a modification to the REMS to remove the use of telecommunication verification (the switch system) for pharmacies to verify safe use conditions Clozapine, the first atypical antipsychotic, is a highly effective medication for patients with schizophrenia who do not respond to other antipsychotics
It is also used to help reduce the risk of suicidal behavior in people with schizophrenia or similar disorders
Clozapine-related seizures appear to be dose-related
Weight gain, Decreased white blood cell count, Extrapyramidal symptoms, Increased liver enzymes, Drowsiness, Seizure, Increased white blood cell count (eosinophils), Anticholinergic Discussion
found electroencephalography (EEG) abnormalities, with an average dose of 305
5 mg, titrate gradually, and use divided dosing
Rash, fever, and swollen lymph nodes
For a summary of the incidence of seizures and EEG abnormalities reported in the literature for clozapine, see
Core Tip: Clozapine-related seizure is a serious adverse reactions of clozapine, which should be given more attention to its early prevention and optimal treatment
If there is clozapine toxicity, the patient should obtain urgent care that includes symptomatic treatment and assessment for serious problems such as cardiac arrhythmias, seizure activity, or systemic infection