Chloramphenicol works by inhibiting protein synthesis by binding to the 50S ribosomal subunit and directly preventing the formation of bacterial
Chloramphenicol is bacteriostatic for most Gram-positive and many Gram-negative aerobic bacteria but can be bactericidal against some very sensitive bacteria
DB00446
positive blood culture Gram-stain (modify when identification and susceptibility results available) Gram-positive cocci, like staphylococci (in clusters) – flucloxacillin plus
Uses for Chloramphenicol
Gram-positive and gram-negative cocci and bacilli (including anaerobes
Because of bone marrow
Subjects: LCSH: Gram-positive bacterial infections
Chloramphenicol is a broad-spectrum antibiotic widely used for treating ophthalmic infections, but concerns about rising bacterial resistance to chloramphenicol
Ferretti A
Chloramphenicol is a white to greyish-white or yellowish-white fine crystalline powder or fine crystals, Like other ribosomal inhibitors, chloramphenicol has a broad spectrum of activity, which includes gram-positive and gram-negative bacteria, anaerobes, and some rickettsial pathogens
Chloramphenicol is not effective against fungi, protozoa, and viruses
In vitro, chloramphenicol exerts mainly a bacteriostatic effect on a wide range of gram-negative and gram-positive bacteria
Chloramphenicol inhibits most Gram-positive bacteria at 10 g/mL concentrations and Gram-negative bacteria at 0
epidermidis, thus usage depends on local susceptibility data Enterococci has two main species - Enterococcus faecalis and Enterococcus faecium; the antibiotics listed are active against E
As a broad-spectrum antibiotic, chloramphenicol spectrum of activity includes Gram
It is evident that gram-positive bacterial pathogens (particularly Staphylococcus aureus and epidermidis) are the most common causes of ocular infections, but a sizable minority is gram-negative (mostly Serratia, Pseudomonas and Moraxella species)
Technically, “antibiotic” refers only to antimicrobials derived from bacteria or molds but is often (including read more that is primarily bacteriostatic
Chloramphenicol should not be used topically because small amounts may be absorbed and, rarely, cause aplastic anemia
coli and S
The cell walls of Gram positive bacteria differ structurally from the cell walls of Gram negative bacteria
Many Gram-positive and Gram-negative bacteria, including some recently discovered H influenzae strains, are resistant to chloramphenicol because they possess the enzyme chloramphenicol transacetylate, which acetylates hydroxyl groups on the chloramphenicol structure